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KMID : 0387419990100020029
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Korean Society of Oriental Neuropsychiatry
1999 Volume.10 No. 2 p.29 ~ p.45
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Effects of Jogihaeatag(調氣解瘀湯) on the Cerebral Cortex Neuron injured by XO/XA
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Lee Yong-Geun
Kang Hyung-Won
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Abstract
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As the average life span has been lengthened and the rate of senile population has been raised, chronic degenerative diseases incident to aging have been increased rapidly and become a social problem. With this social background, recently, oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson’s Disease, Alzheimer Disease. The purpose of this study is to examine the toxic effects caused by Xanthine Oxidase(XO) and the effects of herbal extracts such as Jokihaeatang(JHT) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. X0, an oxygen radical, decreased the survival rate of the cultured cells on NR assay, MTT assay and amount of neurofilaments and increased the amount of lipid peroxidation. 2. JHT have efficacy of increasing the amount of neurofilaments.
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KEYWORD
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